Results

  1. Tomaio JN, Fleury S, Bilder A, Nacimba J, Lakshman A, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K & Mingote S. Evidence for age-related vulnerability in dopamine-glutamate projections to the lateral entorhinal cortex. bioRxiv. 2025.

  2. Shi X, He W, Xu H, Clark L, Zhang HM, Gupta A, Mirle N, Fenno LE, Wang H. Ultrasound-activated drug release with extracellular vesicles. bioRxiv. 2025.

  3. Buck SA, Rubin SA, Kunkhyen T, Treiber CD, Xue X, Fenno LE, Mabry SJ, Sundar VR, Yang Z, Shah D, Ketchesin KD, Becker-Krail DD, Vasylieva I, Smith MC, Weisel FJ, Wang W, Erickson-Oberg MQ, O'Leary EI, Aravind E, Ramakrishnan C, Kim YS, Wu Y, Quick M, Coleman JA, MacDonald WA, Elbakri R, Olsen AL, Rocha EM, Miller GW, De Miranda BR, Palladino MJ, McCabe BD, Fish KN, Seney ML, Rayport S, Mingote S, Deisseroth K, Hnasko TS, Awatramani R, Watson AM, Waddell S, Cheetham CEJ, Logan RW & Freyberg Z. Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration. bioRxiv. 2025.

  4. McGovern DJ, Phillips A, Ly A, Prévost ED, Ward L, Siletti K, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K, Baratta MV, Ford CP & Root DH. Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes. J Neuroscience. 2025.

  5. Chapman PD, Kulkarni AS, Trevisan AJ, Han K, Hinton JM, Deltuvaite P, Fenno LE, Ramakrishnan C, Patton MH, Schwarz LA, Zakharenko SS, Deisseroth K & Bikoff JB. A brain-wide map of descending inputs onto spinal V1 interneurons. Neuron. 2025.

  6. Wang W, Pyatnitskiy I, Shi Y, Tang KWK, Xie Y, Wynn T, Liu X, Hsieh J-C, Jeong J, He W, Artman B, Romero Lozano A, Shi X, Sangani A, Fenno LE, Santacruz S, Chen B & Wang H. Hydrogen-bonded organic framework nanotransducers enabled sono-optogenetics for Parkinsonian rats. bioRxiv. 2025.

  7. Prévost ED, Phillips A, Lauridsen K, Enserro G, Rubinstein B, Alas D, McGovern DJ, Ly A, Hotchkiss H, Banks M, McNulty C, Kim YS, Fenno LE, Ramakrishnan C, Deisseroth K & Root DH. Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons. J Neuroscience. 2024.

  8. Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis C-H, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K & Shah NM. A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2024. [Erratum].

  9. Ratliff JM, Terral G, Lutzu S, Heiss J, Mota J, Stith B, Vazquez Lechuga A, Ramakrishnan C, Fenno LE, Daigle T, Deisseroth K, Zeng H, Ngai J, Tasic B, Sjulson L, Rudolph S, Kilduff TS & Batista-Brito R. Neocortical long-range inhibition promotes cortical synchrony and sleep. bioRxiv. 2024.

  10. Wang H, Flores RJ, Yarur HE, Limoges A, Bravo-Rivera H, Casello SM, Loomba N, Enriquez-Traba J, Arenivar M, Wang Q, Ganley R, Ramakrishnan C, Fenno LE, Kim Y, Deisseroth K, Or G, Dong C, Hoon MA, Tian L & Tejeda HA. Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states. Neuron. 2024.

  11. Martin-Solana E, Carter SD, Donahue EKF, Ning J, Glausier JR, Preisegger MA, Eisenman L, Joseph PN, Bouchet-Marquis C, Wu K, Mobini CL, Frantz AN, Puig S, Hampton CM, Kabbani N, Jensen GJ, Watkins SC, Deisseroth K, Fenno LE, Gold MS, Wills ZP, Burkewitz K, Das S & Freyberg Z. Ribosome-Associated Vesicles promote activity-dependent local translation. bioRxiv. 2024.

  12. Wang W, Tang KWK, Pyatnitskiy I, Liu X, Shi X, Huo D, Jeong J, Wynn T, Sangani A, Baker A, Hsieh J-C, Romero Lozano A, Artman B, Fenno LE, Buch VP & Wang H. Ultrasound-induced cascade amplification in a mechanoluminescent nanotransducer for enhanced sono-optogenetic deep brain stimulation. ACS Nano. 2023.

  13. Azcorra M, Gaertner Z, Davidson C, He Q, Kim H, Nagappan S, Hayes CK, Ramakrishnan C, Fenno LE, Kim YS, Deisseroth K, Longnecker R, Awatramani R & Dombeck DA. Unique functional responses differentially map onto genetic subtypes of dopamine neurons. Nature Neuroscience. 2023.

  14. Sylwestrak EL, Jo Y, Vesuna S, Wang X, Holcomb B, Tien RH, Kim DK, Fenno LE, Ramakrishnan C, Allen WE, Chen R, Shenoy KV, Sussillo D & Deisseroth K. Cell-type-specific population dynamics of diverse reward computations. Cell. 2022.

  15. Fenno LE, Levy R & Yizhar O. Molecular optimization of rhodopsin-based tools for neuroscience applications. Rhodopsin: Methods and Protocols (book chapter). 2022.

  16. Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis C-H, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K & Shah NM. A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022.

  17. Rossi MA, Basiri ML, Liu Y, Hashikawa Y, Hashikawa K, Fenno LE, Kim YS, Ramakrishnan C, Deisseroth K & Stuber GD. Transcriptional and functional divergence in lateral hypothalamic glutamate neurons projecting to the lateral habenula and ventral tegmental area. Neuron. 2021.

  18. Pereira Luppi M, Azcorra M, Caronia-Brown G, Poulin J-F, Gaertner Z, Gatica S, Moreno-Ramos OA, Nouri N, Dubois M, Ma YC, Ramakrishnan C, Fenno LE, Kim YS, Deisseroth K, Cicchetti F, Dombeck DA & Awatramani R. Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins. Cell Reports. 2021.

  19. Gazea M, Furdan S, Sere P, Oesch L, Molnár B, Di Giovanni G, Fenno LE, Ramakrishnan C, Mattis J, Deisseroth K, Dymecki SM, Adamantidis AR & Lőrincz ML. Reciprocal lateral hypothalamic and raphe GABAergic projections promote wakefulness. J Neuroscience. 2021.

  20. Kim CK, Sanchez MI, Hoerbelt P, Fenno LE, Malenka RC, Deisseroth K & Ting AY. A molecular calcium integrator reveals a striatal cell type driving aversion. Cell. 2020.

  21. Fenno LE, Ramakrishnan C, Kim YS, Evans KE, Lo M, Vesuna S, Inoue M, Cheung KYM, Yuen E, Pichamoorthy N, Hong ASO & Deisseroth K. Comprehensive Dual- and Triple-Feature Intersectional Single-Vector Delivery of Diverse Functional Payloads to Cells of Behaving Mammals. Neuron. 2020.

  22. Root DH, Barker DJ, Estrin DJ, Miranda-Barrientos JA, Liu B, Zhang S, Wang H-L, Vautier F, Ramakrishnan C, Kim YS, Fenno LE, Deisseroth K & Morales M. Distinct signaling by ventral tegmental area glutamate, GABA, and combinatorial glutamate-GABA neurons in motivated behavior. Cell Reports. 2020.

  23. Liu J, Kim YS, Richardson CE, Tom A, Ramakrishnan C, Birey F, Katsumata T, Chen S, Wang C, Wang X, Joubert L-M, Jiang Y, Wang H, Fenno LE, Tok JB-H, Pașca SP, Shen K, Bao Z & Deisseroth K. Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals. Science. 2020.

  24. Wu X, Zhu X, Chong P, Liu J, Andre LN, Ong KS, Brinson K Jr, Mahdi AI, Li J, Fenno LE, Wang H & Hong G. Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics. PNAS. 2019.

  25. Rovira-Esteban L, Gunduz-Cinar O, Bukalo O, Limoges A, Brockway E, Müller K, Fenno LE, Kim YS, Ramakrishnan C, Andrási T, Deisseroth K, Holmes A & Hájos N. Excitation of Diverse Classes of Cholecystokinin Interneurons in the Basal Amygdala Facilitates Fear Extinction. ENeuro. 2019.

  26. Hafner G, Witte M, Guy J, Subhashini N, Fenno LE, Ramakrishnan C, Kim YS, Deisseroth K, Callaway EM, Oberhuber M, Conzelmann K-K & Staiger JF. Mapping Brain-Wide Afferent Inputs of Parvalbumin-Expressing GABAergic Neurons in Barrel Cortex Reveals Local and Long-Range Circuit Motifs. Cell Reports. 2019.

  27. Lazaridis I, Tzortzi O, Weglage M, Märtin A, Xuan Y, Parent M, Johansson Y, Fuzik J, Fürth D, Fenno LE, Ramakrishnan C, Silberberg G, Deisseroth K, Carlén M & Meletis K. A hypothalamus-habenula circuit controls aversion. Molecular Psychiatry. 2019.

  28. Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK & Deisseroth K. Structural mechanisms of selectivity and gating in anion channelrhodopsins. Nature. 2018.

  29. Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK & Deisseroth K. Crystal structure of the natural anion-conducting channelrhodopsin GtACR1. Nature. 2018.

  30. Fenno LE, Mattis J, Ramakrishnan C & Deisseroth K. A Guide to Creating and Testing New INTRSECT Constructs. Current Protocols in Neuroscience. 2018.

  31. Yu K, Ahrens S, Zhang X, Schiff H, Ramakrishnan C, Fenno L, Deisseroth K, Zhao F, Luo M-H, Gong L, He M, Zhou P, Paninski L & Li B. The central amygdala controls learning in the lateral amygdala. Nature Neuroscience. 2017.

  32. Allen WE, DeNardo LA, Chen MZ, Liu CD, Loh KM, Fenno LE, Ramakrishnan C, Deisseroth K & Luo L. Thirst-associated preoptic neurons encode an aversive motivational drive. Science. 2017.

  33. Selimbeyoglu A, Kim CK, Inoue M, Lee SY, Hong ASO, Kauvar I, Ramakrishnan C, Fenno LE, Davidson TJ, Wright M & Deisseroth K. Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice. Science Translational Medicine. 2017.

  34. Rivnay J, Wang H, Fenno L, Deisseroth K & Malliaras GG. Next-generation probes, particles, and proteins for neural interfacing. Science Advances. 2017.

  35. Clemente-Perez A, Ritter Makinson S, Higashikubo B, Brovarney S, Cho FS, Urry A, Holden SS, Wimer M, Dávid C, Fenno LE, Acsády L, Deisseroth K & Paz JT. Distinct Thalamic Reticular Cell Types Differentially Modulate Normal and Pathological Cortical Rhythms. Cell Reports. 2017.

  36. Tovote P, Esposito MS, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SBE, Ramakrishnan C, Fenno L, Deisseroth K, Herry C, Arber S & Lüthi A.

    Midbrain circuits for defensive behaviour. Nature. 2016.

  37. Fenno LE, Gunaydin LA & Deisseroth K. Mapping Anatomy to Behavior in Thy1:18 ChR2-YFP Transgenic Mice Using Optogenetics. Cold Spring Harbor Protocols. 2015.

  38. Yamamoto K, Tanei Z-I, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukayama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K & Iwatsubo T. Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease. Cell Reports. 2015.

  39. Cheng MY, Wang EH, Woodson WJ, Wang S, Sun G, Lee AG, Arac A, Fenno LE, Deisseroth K & Steinberg GK. Optogenetic neuronal stimulation promotes functional recovery after stroke. PNAS. 2014.

  40. Fenno LE, Mattis J, Ramakrishnan C, Hyun M, Lee SY, He M, Tucciarone J, Selimbeyoglu A, Berndt A, Grosenick L, Zalocusky KA, Bernstein H, Swanson H, Perry C, Diester I, Boyce FM, Bass CE, Neve R, Huang ZJ & Deisseroth K. Targeting cells with single vectors using multiple-feature Boolean logic. Nature Methods. 2014.

  41. Gunaydin LA, Grosenick L, Finkelstein JC, Kauvar IV, Fenno LE, Adhikari A, Lammel S, Mirzabekov JJ, Airan RD, Zalocusky KA, Tye KM, Anikeeva P, Malenka RC & Deisseroth K. Natural Neural Projection Dynamics Underlying Social Behavior. Cell. 2014.

  42. Fenno LE & Deisseroth K. Neocortical Circuit Interrogation with Optogenetics. Optical Imaging of Neocortical Dynamics (book chapter). 2013.

  43. Fenno LE & Deisseroth K. Optogenetic Tools for Control of Neural Activity. Optical Imaging of Neocortical Dynamics (book chapter). 2013.

  44. Mattis J, Tye KM, Ferenczi EA, Ramakrishnan C, O’Shea DJ, Prakash R, Gunaydin LA, Hyun M, Fenno LE, Gradinaru V, Yizhar O & Deisseroth K. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nature Methods. 2012.

  45. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O’Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P & Deisseroth K. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature. 2011.

  46. Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A, Cushman J, Polle J, Magnuson J, Hegemann P & Deisseroth K. The Microbial Opsin Family of Optogenetic Tools. Cell. 2011.

  47. Byers B, Cord B, Nguyen HN, Schule B, Fenno L, Lee PC, Deisseroth K, Langston JW, Reijo Pera R & Palmer TD. SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress. PLoS One. 2011.

  48. Paz JT, Bryant AS, Peng K, Fenno L, Yizhar O, Frankel WN, Deisseroth K & Huguenard JR. A new mode of corticothalamic transmission revealed in the Gria4−/− model of absence epilepsy. Nature Neuroscience. 2011.

  49. Fenno L, Yizhar O & Deisseroth K. The Development and Application of Optogenetics. Annual Review of Neuroscience. 2011.

  50. Yizhar O, Fenno LE, Davidson TJ, Mogri M & Deisseroth K. Optogenetics in Neural Systems. Neuron. 2011.

  51. Tye KM, Prakash R, Kim S-Y, Fenno LE, Grosenick L, Zarabi H, Thompson KR, Gradinaru V, Ramakrishnan C & Deisseroth K. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature. 2011.

  52. Yizhar O, Fenno L, Zhang F, Hegemann P & Deisseroth K. Microbial opsins: a family of single-component tools for optical control of neural activity. Cold Spring Harbor Protocols. 2011.

  53. Paralikar K, Cong P, Yizhar O, Fenno LE, Santa W, Nielsen C, Dinsmoor D, Hocken B, Munns GO, Giftakis J, Deisseroth K & Denison T. An implantable optical stimulation delivery system for actuating an excitable biosubstrate. IEEE Journal of Solid-State Circuits. 2011.

  54. Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim D-S, Fenno LE, Ramakrishnan C & Deisseroth K. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature. 2010.

  55. Airan RD, Thompson KR, Fenno LE, Bernstein H & Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature. 2009.

  56. Fenno LE, Ptaszek LM & Cowan CA. Human embryonic stem cells: emerging technologies and practical applications. Current Opinion in Genetics & Development. 2008.

  57. Fenno LE & Cowan CA. Adult Stem Cells. Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine (book chapter). 2008.